500 million years ago:
– 1st appearance of endothelium
1 million years ago :
– Boyd Eaton
300 B.C. :
– Erasistratus: The Air-Pneuma theory
200 A.D. :
– Galen blood theory
1616 :
– Harvey, Theory of Circulation: Metaphor, the circle
1664 :
- Thomas Willis: The Circle of Willis
1794:
- Atwan Lavoisier : Nitroglycerin
1850 :
– Jean Charcot: Neuropathic Principle of Arthropathy
1866 :
– Alfred Nobel: Invention of Dynamite/Nitroglycerin with diatomaceous earth
1970 :
– Endothelial Relaxing Factor: Murad
1972 :
– McComas and Upton: Double Crush
1982 :
– Dellon: Multiple Crush Syndrome
1998 :
– Murad, Ignarro and Furchgott
2005 :
– Cooke: ADMA
2009 :
– Vinik: Small Fiber Neuropathy
2009 :
– Blau: Tetrahydrobiopterin (BH4)