500 million years ago: – 1st appearance of endothelium

1 million years ago : – Boyd Eaton

300 B.C. : – Erasistratus: The Air-Pneuma theory

200 A.D. : – Galen blood theory

1616 : – Harvey, Theory of Circulation: Metaphor, the circle

1664 : - Thomas Willis: The Circle of Willis

1794: - Atwan Lavoisier : Nitroglycerin

1850 : – Jean Charcot: Neuropathic Principle of Arthropathy

1866 : – Alfred Nobel: Invention of Dynamite/Nitroglycerin with diatomaceous earth

1970 : – Endothelial Relaxing Factor: Murad

1972 : – McComas and Upton: Double Crush

1982 : – Dellon: Multiple Crush Syndrome

1998 : – Murad, Ignarro and Furchgott

2005 : – Cooke: ADMA

2009 : – Vinik: Small Fiber Neuropathy

2009 : – Blau: Tetrahydrobiopterin (BH4)