500 million years ago: – 1st appearance of endothelium 1 million years ago : – Boyd Eaton 300 B.C. : – Erasistratus: The Air-Pneuma theory 200 A.D. : – Galen blood theory 1616 : – Harvey, Theory of Circulation: Metaphor, the circle 1664 : - Thomas Willis: The Circle of Willis 1794: - Atwan Lavoisier : Nitroglycerin 1850 : – Jean Charcot: Neuropathic Principle of Arthropathy 1866 : – Alfred Nobel: Invention of Dynamite/Nitroglycerin with diatomaceous earth 1970 : – Endothelial Relaxing Factor: Murad 1972 : – McComas and Upton: Double Crush 1982 : – Dellon: Multiple Crush Syndrome 1998 : – Murad, Ignarro and Furchgott 2005 : – Cooke: ADMA 2009 : – Vinik: Small Fiber Neuropathy 2009 : – Blau: Tetrahydrobiopterin (BH4)